An Isatin beta-thiosemicarbazone (IBT)-dependent Mutant of Vaccinia Virus: The Nature of the IBT-dependent Step
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چکیده
منابع مشابه
Synthesis of vaccinia viral antigens in HeLa cells in the presence of isatin beta-thiosemicarbazone.
Vaccinia virus antigens, in HeLa cells treated with the antipox virus drug isatin beta-thiosemicarbazone (IBT), were analyzed by immunoprecipitation, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The total radioactivity in the immunoprecipitate was decreased to almost 50% in the presence of the drug as compared to its absence. An inhibition also occurred with an IBT-dep...
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A fatal case of vaccinia necrosum treated with antivaccinial gamma globulin and N-methyl isatin beta-thiosemicarbazone (33T57) is described. Histological abnormalities found at necropsy included intranuclear as well as cytoplasmic inclusion bodies, absence of lymphoid germinal centres, grey hepatization, and bronchiolar epithelial hyperplasia. Virus titres were highest in the original skin lesi...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1973
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-21-3-477